Priv.-Doz. Dr. med. Stefan Kääb
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Medizinische Klinik und Poliklinik I Klinikum der Universität München Großhadern (LMU - Großhadern) Marchioninistr. 15 81377 München Tel + 49(0)89 7095-3049 Fax + 49(0)89 7095-6076 e-mail: stefan.kaab@med.uni-muenchen.de |
Education and professional training |
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| 1969 - 1982 | Primary and secondary school in Munich 1973-1980 (classical Gymnasium), 1979-1980 Carrisbrooke Castle Highschool, Isle of Wight England |
| 1982 - 1983 | Community Service, Munich |
| 1983 - 1984 | University of Salzburg, Austria: biology |
| 1984 - 1993 | Ludwig-Maximilians-University: medicine 1990 Medical Licence 1990-1993 Intern and Resident, Department of Medicine 1, LMU-Klinikum Grosshadern 1993 Dissertation: Predictive parameters for Postoperative Sepsis (summa cum laude) K. Werdan, advisor |
| 1993 - 1995 | Postdoctoral Fellow, (DFG fellowship Johns Hopkins University, Baltimore, USA (Prof. E. Marban and Prof. G. Tomaselli |
| 1996 - 2000 | Fellow in Cardiology, Department of Medicine 1, LMU-Klinikum Grosshadern, G. Steinbeck, Director Dept. Medicine - Cardiology |
| Since 2000 | Active full time staff, Department of Medicine 1, LMU-Klinikum Grosshadern, G. Steinbeck, Director Dept. Medicine - Cardiology |
| Since 1998 | Faculty, Munich-Harvard Educational Alliance |
| Since 2001 | Coordinator Munich Alliance for Genomic Research on Cardiac Arrhythmias (as local coordinator of the National Genome Research network (NGFN)), Member of the scientific steering committee cardiovascular diseases network within NGFN |
| 2004 | Habilitation: Mechanisms of altered myocardial repolarization |
Teaching
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| Since 1996 | Seminars in internal medicine, cardiovascular course, arrhythmias, ECG |
| Since 1997 | Program of Advanced Medical Education Harvard School and LMU Munich Teaching Courses |
| Since 2002 | Member of the Committee for the development of curriculum at the Medical Faculty in Munich |
| Since 2003 | Member of the Poject group MeCuM-LMU |
Areas of research interest
- epidemiology, risk stratification and genetics of sudden cardiac death
- population genetics of cardiovascular diseases
- functional genetics of cardiac arrhythmias (monogenic and polygenic aspects)
- genetic determinants of normal human electrophysiology (repolarization) and their effects on common arrhythmias
References (top 10):
Kääb S, Miguel-Velado E, López-López JR, Pérez-Garcia T. Down Regulation of Kv3.4 Channels By Chronic Hypoxia Increases Acute Oxygen Sensitivity in Rabbit Carotid Body. J Physiol. 2005 May 12; [Epub ahead of print].
Barth AS; Merk S; Arnoldi E; Zwermann L; Kloos P; Gebauer M; Steinmeyer K; Bleich M; Kääb S; Hinterseer M; Kartmann H; Kreuzer E; Dugas M; Steinbeck G; Nabauer M. Reprogramming of the human atrial transcriptome in permanent atrial fibrillation: expression of a ventricular-like genomic signature. 2005 Circ Res. 2005; Vol. 96(9),1022-9
Pfeufer A, Jalilzadeh S, Perz S, Mueller JC, Hinterseer M , Illig T, Akyol M, Huth C, Schopfer-Wendels A, Kuch B, Steinbeck G, Holle R, Näbauer M, Wichmann HE, Meitinger T, Kääb S. Common Variants in Myocardial Ion Channel Genes Modify the QT-Interval in the General Population. Results From the KORA Study. Circ Res. 2005; Vol. 96 (6), 693-701
Kääb S, Barth AS, Dugas M, Margerie D, Pfeufer A, Gebauer M, Zwermann L, Merk S, Steinmeyer K, Bleich M, Kreuzer E, Steinbeck G, Näbauer M. Global gene expression in human mycardium ? Oligonucleotide microarray analysis of regional diversity and transcriptional regulation in heart failure. J Mol Med. 2004; 82: 308-316
Kääb S, Hinterseer M, Näbauer, Steinbeck G. Sotalol testing unmasks altered repolarization in patients with suspected acquired long-QT-syndrome - a case-control pilot study using i.v. sotalol. Eur Heart J. 2002; 24: 649-657.
Nuss HB, Kääb S, Kass DA, Tomaselli GF, Marban E. Cellular basis of ventricular arrhythmias and abnormal automaticity in heart failure. Am J Physiol Heart Circ Physiol. 1999; 277:46-51.
Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF. Molecular Basis of transient outward potassium current downregulation in human heart failure ? A decrease in Kv4.3 mRNA correlates with a reduction in current density. Circulation.1998; 14: 1383-93.
Pak PH, Nuss HB, Tunin RS, Kääb S, Tomaselli GF, Marban E, Kass DA. Repolarization abnormalities, arrhythmia and sudden death in canine tachycardia-induced cardiomyopathy. J Am Coll Cardiol. 1997; 30: 576-84.
Nuss HB, Johns DC, Kääb S, Tomaselli GF, Kass D, Lawrence JH, Marban E. Reversal of potassium channel deficiency in cells from failing hearts by adenoviral gene transfer: a prototype for gene therapy for disorders of cardiac excitability and contractility. Gene Therapy 1996;3:900-912.
Kääb S, Nuss HB, Chiamvimonvat N, O'Rourke B, Tunin RS, Pak PH, Kass DA, Marban E, Tomaselli GF. Mechanisms of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ Res. 1996;78:262-273.